Chlorpromazine and Allied Substances

Chlorpromazine and allied substances.

Promethazine (phenergan) has two methyl groups, which in these derivatives are associated with strong antihistaminic power, while chlorpromazine is a propylamine phenothiazine, which has more marked central nervous system effects but only one-hundredth of the antihistamine potency of promezathine. The Department of Pharmacology at Oxford has pointed out (Burns, 1948; Burns and Dutta, 1948; Dews...

The iodimetric titration of cysteine and allied substances.

THE increasing interest of biochemists in sulphydryl compounds has led to the necessity of finding some method for the accurate determination of these substances. That the problem is complex may be judged from the number of papers proposing new methods or modifications of old ones. The original procedure of Rosenheim and Davidsohn [1904] for the volumetric estimation of thiol acids by the use o...

Inhibition of peristalsis in guineapig ileum by steroids and allied substances.

Many workers have shown that certain steroids inhibit the contraction of different smooth muscles produced by various spasmogens. The effect of different steroids on the contractions produced by physiological method of stimulating the intestine by raising the intraluminal pressure was studied. The method followed was that of Trendelenburg for recording peristalsis in guineapigs ileum. It has be...

Chlorpromazine hydrochloride

Major use Chlorpromazine hydrochloride (CPH) belongs to antipsychotic drugs, also called neuroleptics; and it is mainly used for the treatment of neurological disorders. CPH has sedative, hypotensive and antiemetic properties. CPH, which is an aliphatic phenothiazine, was first synthesized in 1952. It was extensively studied and used as a model for a big class of neuroleptic agents. Haloperidol...

Arthritis and Allied Conditions